Registration Dossier
Registration Dossier
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EC number: 417-040-3 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Klimish: 1
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Adult animals dosed with COAG-122 at doses of up to 1000 mg/kg/day showed minimal evidence of adverse response. During the first week of treatment effects were seen on male bodyweight at the high dose level but the animals quickly recovered to show normal growth patterns through the rest of the study. Reversible effects in the first week are not considered to equate to an "adverse" response.
Short description of key information:
It was concluded that the No-Observed-Adverse-Effect-Level (NOAEL) for COAG-122 was in excess of 1000 mg/kg/day (the limit dose) for reproductive performance and offspring growth and survival in the CD rat following oral gavage administration in a standard screening test.
Effects on developmental toxicity
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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