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EC number: 229-851-8
CAS number: 6786-83-0
No indication of skin sensitization observed.
Skin sensitization study for test
chemical was conducted in guinea pig using modified Buehler and
Klecak method for open Epicutaneous testing.
For the induction phase, the left
flanks of 10 albino guinea pigs were shaved and the dye test material
applied three times weekly (Monday, Wednesday Friday) for three
consecutive weeks. Each animal received 0.1 ml of the dye test material
over a 1.8-cm circular area. After a rest period of two weeks. In
challenge phase the right flank of each guinea pig was shaved and
exposed to three different concentration10.0%, 5.0%, and
2.5%.Twenty-four hours after the last induction and challenge
application, the animals were depilated to clearly observe dermal
No erythema/edema was observed after
application of test material .The test result was observed to be
negative for the test substance. Therefore the test chemical was
considered to be not sensitizing to the skin of guinea pig using
modified Buehler and Klecak method for open Epicutaneous testing .
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