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EC number: 229-851-8
CAS number: 6786-83-0
Dose: 2000 mg/ kg
Body Weight (gram)
Body Weight Change (%)
Dose: 2000 mg/kg body weight
Hour(s) - Day 0
Days of Observation (0 to 14)
No mortality and morbidity
Acute dermal toxicity study was
performed as per OECD No. 402 by using the given test chemical in Wistar
Rats. Five male and five female healthy young adult rats were randomly
selected and used for conducting acute dermal toxicity study. Rats free
from injury and irritation of skin were selected for the study. Twenty
four hours prior to dermal application of test item, approximately 10%
of body surface area of each rat was clipped. A limit dose of 2000 mg/
kg body weight of test item moistened with 0.2 ml distilled water was
applied by single dermal application and observed for 14 days after
treatment. On test day 0, anamount oftestitem moistened with 0.2 ml
distilled water was applied directly on the intact skin of clipped area
of rats; the porous gauze dressing was put on to the intact skin of
All the animals were observed with
normal clinical signs throughout the experimental period. No mortality
was observed at limit dose of 2000 mg/kg body weight of test item during
the 14 day observation period.
In males, mean body weight was
observed with increase on day 7 and 14, as compared to day 0. In
females, mean body weight was observed with decrease on day 7 and
increase on day 14, as compared to day 0.The external and internal gross
pathological observation of all terminally sacrificed animals did not
show any pathological abnormality.
Under the condition of the study, the
acute dermal median lethal dose (LD50) of the given test chemical was
considered to be >2000 mg/kg body weight. Thus by considering the CLP
criteria for acute toxicity rating for the chemicals, it infers that the
given test chemical does not exhibit acute dermal toxicity i.e it is
acutely non toxic to animals.
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