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EC number: 229-851-8
CAS number: 6786-83-0
In Treated area Dose:500
mg of test item (moistened with 0.5 ml distilled water) Sex:Male
In Control areaDose:0.5
ml of distilled
Key: h =
= Very slight erythema(barely
slight oedema (barely perceptible)
Mean Individual Animal Score at 24,
48 and 72 hours
Body Weight (kg)
Prior to Dosing
Days (Post dosing Observation)
./. = Not Applicable. 1 = Normal
Irritation/corrosion Study of the test chemical
was carried out in Rabbits, This
study was performed as per OECD guideline No. 404.
healthy young adult male rabbits were used for conducting acute dermal
irritation study.Body weights were recorded on day 0 (prior to
application) and at termination.
good intact skin were selected for the study. The hairs of all the
rabbits were clipped at contralateral sites, approximately 24 hours
prior to treatment.A
dose of 0.5 ml of test item (as
such) was applied to the skin,over an area of approximately
6 x 6 cm clippedof hair on one
side of rabbits.The other untreated side was kept as
control area and 0.5 ml of
distilled water was applied at this site. At the end of 4
hours, the gauze patch was removed and test item application site was
wiped with water without altering the integrity of the epidermis.
Initially, the test item was applied
to the clipped area of skin of one rabbit. The test site was covered
with gauze patch.After
4 hours of exposure in animal no. 1, there was very slight erythema
(barely perceptible) and very slight oedema (barely perceptible)
observed at 1 hour of observation. At 24 hour very slight erythema
(barely perceptible) and no oedema was observed.Hence the
confirmatory test was conducted on additional two animal (No. 2 and 3)to
confirm the non irritant nature of the test item. At 48 and 72 hours
observation no erythema and no oedema was observed in animal no 1.
was removed after 4 hours and rabbits wereobservedfor erythema and
oedemaat 1, 24, 48 and 72 hours after patch removal, evaluatedand graded
as per draize method.In animals no. 2 and 3 at 1 hour observation post
patch removal, revealedvery slight erythema (barely perceptible) and
very slight oedema (barely perceptible). At 24 hour observation post
patch removal, revealed very slight erythema (barely perceptible) and no
oedema in aniaml no. 2 whereasvery slight erythema (barely perceptible)
and very slight oedema (barely perceptible), in animal no. 3. At 48 hour
post patch removal very slight erythema (barely perceptible) and no
oedema was observed in animal no. 2 and 3. At 72 hour post patch
removal, both the animals recovered to normal.
The individual mean score at 24, 48 and 72
hours for animal nos. 1, 2 and 3 were 0.33, 0.67, 0.67 and 0.00, 0.00,
0.33, for erythema and oedema formation, respectively. Hence, it was
concluded that the test chemical was Non-Irritating to the skin of male
New Zealand White rabbits under the experimental conditions as per CLP
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