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EC number: 247-426-5
CAS number: 26040-51-7
There were no signs of reaction to treatment with FR-45B. Slightly low
overall bodyweight gain was recorded for females receiving the highest
dietary concentration of FR-458. Males treated with FR-458 were
unaffected. Marginally low alanine amino-transferase activities were
seen in females receiving the highest dietary concentration of FR-458,
and marginally low phosphorus concentrations were seen in all females
and males receiving the highest dietary concentration of FR-458. Urinary
composition was unaffected by treatment with FR-458.
There were no organ weight changes and no treatment-related
histopathological changes in rats that received FR-458.
Di-2 -ethylhexylphthalate (DEHP) - positive control substance:
Hairloss from the dorsal surface of rats receiving DEHP was recorded
from the second week of treatment. Markedly low food consumption and
bodyweight gain, and high food conversion ratio, were recorded for rats
receiving DEHP. Rats receiving DEHP had higher platelet numbers than
controls. Changes in rats receiving DEHP were minor and comprised high
alkaline phosphatase activities, urea and albumin concentrations and
albumin to globulin ratios in males, and low alanine and aspartate
amino-transferase activities in females.
Organ weight analysis indicated markedly high liver and markedly low
testes weights in rats receiving DEHP. At necropsy males receiving DEHP
were found to have small, flaccid testes. Histopathological changes in
animals that received DEHP comprised panacinar hepatocytic granular
eosinophilic extensive cytoplasm in males and females, a lack of
centriacinar hepatocytic glycogen in males, and a lack of germinal
epithelium in the testes.
Bis(2-ethylhexyl) tetrabromophthalate was administered via the diet to
three groups of ten male and ten female CD rats at concentrations of
200, 2 000 or 20 000 ppm (= ca. 21.97, 223.4 or 2331 mg/kg/day) for four
weeks. At the end of the treatment period all animals were killed and
necropsied. The pathologic evaluation consisted of organ weight, gross
and microscopic examination of reproductive organs, incl. epididymides,
mammary glands - caudal, ovaries, prostate, testes, and uterus (with
No clinical signs and no organ weight changes and histopathological
changes in reproductive organs were found in male and female rats
treated with 200, 2 000 or 20 000 ppm (= ca. 21.97, 223.4 or 2331
mg/kg/day) bis(2-ethylhexyl) tetrabromophthalate.
Therefore, the NOAEL for fertility is 20 000 ppm (ca. 2331 mg/kg bw).
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