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EC number: 247-426-5 | CAS number: 26040-51-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- The potential of RC9927 to cause damage to the conjunctivae, iris or cornea was assessed in 3 male and 3 female New Zealand White rabbits, each subject to single ocular instillation of 0.1 ml of the test material. Ocular reactions were examined 1, 24, 48 and 72 hours after treatment according to Draize.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bis(2-ethylhexyl) tetrabromophthalate
- EC Number:
- 247-426-5
- EC Name:
- Bis(2-ethylhexyl) tetrabromophthalate
- Cas Number:
- 26040-51-7
- Molecular formula:
- C24H34Br4O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate
- Test material form:
- liquid
- Details on test material:
- RC 9927 (batch 6159-199-3), also identified as FR-45B, a slightly turbid, viscous pale yellow liquid received from Pennwalt Corporation on 1st September 1986.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 72 hours (no information if eyes were washed)
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3 male and 3 female animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable, score = 0 at any time point
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable, score = 0 at any time point
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable, score = 0 at any time point
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable, score = 0 at any time point
Any other information on results incl. tables
A crimson-red appearance to the conjunctiva or slight injection of the conjunctival blood vessels and an ocular discharge, were observed among the rabbits one hour after instillation of RC9927. No other change was apparent. All ocular irritation responses had resolved by the 24-hour examination.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The potential of RC9927 to cause damage to the conjunctivae, iris or corneawas assessed in 3 male and 3 female New Zealand White rabbits, each subject to single ocular instillation of 0.1 ml of the test material. Ocular reactions were examined 1, 24, 48 and 72 hours after treatment according to Draize.
A crimson-red appearance to the conjunctiva or slight injection of the conjunctival blood vessels and an ocular discharge, were
observed among the rabbi ts one hour after instillation of RC9927. No other change was apparent. All ocular irritation responses had resolved by the 24-hour examination.
Under the conditions of this test, RC9927 was not irritating to the eye.
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