Registration Dossier
Registration Dossier
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EC number: 247-426-5 | CAS number: 26040-51-7
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Remarks:
- Specific investigations: Biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- In vitro and in ovo effects of four brominated flame retardants on toxicity and hepatic mRNA expression in chicken embryos
- Author:
- Egloff C, Crump D, Chiu S, Manning G, McLaren KK, Cassone CG, Letcher RJ, Gauthier LT, Kennedy SW
- Year:
- 2 011
- Bibliographic source:
- Toxicol Lett., 207, 25-33 (2011)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Several brominated flame retardants were administrated to chicken embryonic hepatocytes (CEH) to determine cytotoxicity and changes in relative mRNA abundance of 11 genes involved in xenobiotic metabolism, lipid metabolism and thyroid hormone (TH) homeostasis by real-time reverse transcription-PCR.
- GLP compliance:
- no
- Type of study / information:
- in vitro
Test material
- Reference substance name:
- Bis(2-ethylhexyl) tetrabromophthalate
- EC Number:
- 247-426-5
- EC Name:
- Bis(2-ethylhexyl) tetrabromophthalate
- Cas Number:
- 26040-51-7
- Molecular formula:
- C24H34Br4O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate
Constituent 1
- Specific details on test material used for the study:
- Purity > 98 %
Results and discussion
Any other information on results incl. tables
Test concentrations in the range of 7.06 and 21.2 mg/L of bis(2-ethylhexyl) tetrabromophthalate (BEHTBP) did not affect hepatocyte viability.
Applicant's summary and conclusion
- Conclusions:
- Test concentrations in the range of 7.06 and 21.2 mg/L of bis(2-ethylhexyl) tetrabromophthalate (BEHTBP) did not affect hepatocyte viability.
- Executive summary:
In this study in vitro effects of bis(2-ethylhexyl) tetrabromophthalate (BEHTBP) with respect to hepatic mRNA expression in chicken embryos (Gallus gallus domesticus) was investigated. In the the study primary cultures of chicken embryonic hepatocytes (CEH) were used. It was reported that test concentrations in the range of 7.06 and 21.2 mg/L of bis(2-ethylhexyl) tetrabromophthalate (BEHTBP) did not affect hepatocyte viability.
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