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EC number: 247-426-5
CAS number: 26040-51-7
TBPH showed no effects on fetal testosterone production, survival and
maternal weight gain and was thus considered as negative in this
In a short term in vivo screening assay of Furr et al. (2014) termed
Fetal Phthalate Screen (FPS) 3 pregnant rats per group were dosed by
gavage from gestational day (GD) 14 to 18 at one dose level (750 mg/kg
bw per day) with one of 27 chemicals, e.g. several phthalate esters and
other chemicals suspected of being endocrine modulators. TBPH was
included as chemical with ‘unknown activity’. The period of GD 14-18 is
described as the ‘critical period for sexual differentiation’. On GD 18
testis testosterone production was measured ex vivo from 3 males per
litter from three litters per chemical. TBPH showed no effects on fetal
testosterone production, survival and maternal weight gain and was thus
considered as negative in this screening assay.
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