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EC number: 247-426-5 | CAS number: 26040-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
A valid acute oral study according OECD 401 (limit test) and dermal toxicity study according OECD 402 is available. No acute inhalation study is on hand.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Groups of 5 male and 5 female rats were administered by gavage a single oral dose of 5000 mg/kg bw of the test material. Animals were observed for mortality, clinical signs and body weight for 14 days. A complete necropsy was performed on each rat.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Remarks:
- 50% v/v solution
- Doses:
- 1 dose of 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female rats/dose
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died during the course of the study.
- Clinical signs:
- other: There were no signs of reaction to treatment with RC9927.
- Gross pathology:
- Necropsy findings on Day 15 were confined to single observations of occasional dark areas on the thymus and fluid distensions of the uterus. Neither of these lesions were considered to reflect an effect of treatment with RC9927.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Discriminating dose > 5000 mg/kg bw.
- Executive summary:
Groups of 5 male and 5 female rats were administered by gavage a single oral dose of 5000 mg/kg bw of the test material. Animals were observed for mortality, clinical signs and body weight for 14 days. A complete necropsy was performed on each rat.
No animals died during the course of the study. There were no signs of reaction to treatment with RC9927. All animals achived normal body weight gains during the 14-day observation period. No relevant necropsy findings on Day 15 were reported.
Under the conditions of this study, the acute oral medium lethal doseage (LD50) of the test material RC 9927 was greater than 5000 mg/kg bw.
Reference
No animals died during the course of the study. There were no signs of reaction to treatment with RC9927. All animals achived normal body weight gains during the 14-day observation period. Necropsy findings on Day 15 were confined to single observations of occasional dark areas on the thymus and fluid distensions of the uterus. Neither of these lesions were considered to reflect an effect of treatment with RC9927.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail und are sufficient for evaluation
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Groups of 5 male and 5 female rats were administered a single dose of 2 ml of the test material per kg bw to the shaved intact site on the back for 24 hours. The animals were observed for mortality, clinical signs and body weight for 14 days. A complete necropsy was performed on each rabbit.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2 ml/kg bw (= 3.09 g/kg bw)
- No. of animals per sex per dose:
- 5 male and 5 female animals/dose
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 2 ml/kg bw (= 3.09 g/kg bw)
- Mortality:
- No animal died during the course of the study.
- Clinical signs:
- other: There were no local or systemic signs of reaction to treatment, following percutaneous treatment with RC9927.
- Gross pathology:
- Necropsy on Day 15 revealed dark thyroids, thymus, lungs and salivary glands, petechiae of the thymus and/or abnormal gastrointestinal contents in the majority of animals. However, these are common findings for rabbits at this laboratory and were not considered to be related to treatment with the testmaterial.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Discriminating dose of the test substance was greater than 2 ml/kg (= 3.09 g/kg bw).
- Executive summary:
Groups of 5 male and 5 female rats were administered a single dose of 2 ml of the test material per kg bw to the shaved intact site on the back for 24 hours. The animals were observed for mortality, clinical signs and body weight for 14 days. A complete necropsy was performed on each rabbit.
No animal died during the course of the study. There were no local or systemic signs of reaction to treatment, following percutaneous treatment with RC9927. All animals achived normal body weight gains during the 14-day observation period. Necropsy on Day 15 revealed dark thyroids, thymus, lungs and salivary glands, petechiae of the thymus and/or abnormal gastrointestinal contents in the majority of animals. However, these are common findings for rabbits at this laboratory and were not considered to be related to treatment with the testmaterial. Pale staining around the nares or occasional areas of exfoliation at the dermal application site were also recorded for single animals.
Under the conditions of this study, the acute percutaneous median lethal dosage (LD50) of the test substance was greater than 2 ml/kg (= 3.09 g/kg bw).
Reference
No animal died during the course of the study. There were no local or systemic signs of reaction to treatment, following percutaneous treatment with RC9927. All animals achived normal body weight gains during the 14-day observation period. Necropsy on Day 15 revealed dark thyroids, thymus, lungs and salivary glands, petechiae of the thymus and/or abnormal gastrointestinal contents in the majority of animals. However, these are common findings for rabbits at this laboratory and were not considered to be related to treatment with the testmaterial. Pale staining around the nares or occasional areas of exfoliation at the dermal application site were also recorded for single animals.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail und are sufficient for evaluation
Additional information
In the acute oral toxicity study groups of 5 male and 5 female rats were administered by gavage a single oral dose of 5000 mg/kg bw of the test material. Animals were observed for mortality, clinical signs and body weight for 14 days. A complete necropsy was performed on each rat. No animals died during the course of the study. There were no relevant signs of reaction to treatment with bis(2-ethylhexyl) tetrabromophthalate.
In the acute dermal toxicity study groups of 5 male and 5 female rats were administered a single dose of 2 ml (3.09 mg/kg bw) of the test material per kg bw to the shaved intact site on the back for 24 hours. The animals were observed for mortality, clinical signs and body weight for 14 days. A complete necropsy was performed on each rabbit. No animal died during the course of the study. There were no local or relevant systemic signs of reaction to treatment, following percutaneous treatment with bis(2-ethylhexyl) tetrabromophthalate.
Justification for classification or non-classification
In the acute oral toxicity study a LD50 > 5000 mg/kg bw and in the acute dermal toxicity study a LD50 > 2000 mg/kg bw was found.
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
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