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EC number: 247-426-5
CAS number: 26040-51-7
A parallelogram approach was used to predict human dermal absorption and
flux for BEH-TEBP. [14C]-BEH-TEBP (BEH-TEBP = bis(2-ethylhexyl)
tetrabromophthalate) was applied to human or rat skin at 100 nmol/cm²
using a flow-through system. Intact rats received analogous dermal
doses. Treated skin was washed and tape-stripped to remove “unabsorbed”
[14C]-radioactivity after continuous exposure (24 h). “Absorbed” was
quantified using dermally retained [14C]-radioactivity; “penetrated” was
calculated based on [14C]-radioactivity in media (in vitro) or excreta +
tissues (in vivo).
BEH-TEBP in vitro penetrance was minimal (< 0.01%) for rat or human
skin. BEH-TEBP absorption was 12± 11% for human skin and 41± 3% for rat
skin. In vivo, total absorption was 27±9%; 1.2% reached systemic
circulation. In vitro maximal BEH-TEBP flux was 0.3±0.2 and 1±0.3
pmol-eq/cm²/h for human and rat skin; in vivo maximum flux for rat skin
was 16±7 pmol-eq/cm2/h. BEH-TEBP-derived [14C]-radioactivity in the
perfusion media could not be characterized. <1% of the dose of BEH-TEHP
is estimated to reach the systemic circulation following human dermal
exposure under the conditions tested.
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