Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-426-5 | CAS number: 26040-51-7
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: surveillance data
- Adequacy of study:
- supporting study
- Study period:
- 2015
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Association between serum polybrominated diphenyl ethers, new flame retardants and thyroid hormone levels for school students near a petrochemical complex, South China
- Author:
- Guo L-C et al
- Year:
- 2 018
- Bibliographic source:
- Chemosphere 202 (2018) 476-482
Materials and methods
- Endpoint addressed:
- other: blood concentrations and association to thyroid hormone levels
- Principles of method if other than guideline:
- no Guideline followed
Test material
- Reference substance name:
- Bis(2-ethylhexyl) tetrabromophthalate
- EC Number:
- 247-426-5
- EC Name:
- Bis(2-ethylhexyl) tetrabromophthalate
- Cas Number:
- 26040-51-7
- Molecular formula:
- C24H34Br4O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
In the this publication 174 school students living in a high pollution area (near a petrochemical complex) in South China (average age 10) were included to collect data and examine the influence of flame retardants on thyroid hormone (TH; serum T3 and T4; free T3 and T4 i.e. FT3 and FT4) and thyroid-stimulating hormone (TSH) levels. The median level of TBPH in the blood samples of school students was 6.6 ng/g lipid (mean 11 ng/g lipid). The frequency of detection is given with 83%. No control group was included in this investigation. The authors postulate positive/negative associations (linear trends) with the sums of blood concentrations of several chemicals via multiple linear regression analysis. No information is given on a potential activity of TBPH alone.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
