Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

exposure-related observations in humans: other data
Type of information:
other: surveillance data
Adequacy of study:
supporting study
Study period:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference Type:
Association between serum polybrominated diphenyl ethers, new flame retardants and thyroid hormone levels for school students near a petrochemical complex, South China
Guo L-C et al
Bibliographic source:
Chemosphere 202 (2018) 476-482

Materials and methods

Endpoint addressed:
other: blood concentrations and association to thyroid hormone levels
Principles of method if other than guideline:
no Guideline followed

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-ethylhexyl) tetrabromophthalate
EC Number:
EC Name:
Bis(2-ethylhexyl) tetrabromophthalate
Cas Number:
Molecular formula:
1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate

Results and discussion

Applicant's summary and conclusion

Executive summary:

In the this publication 174 school students living in a high pollution area (near a petrochemical complex) in South China (average age 10) were included to collect data and examine the influence of flame retardants on thyroid hormone (TH; serum T3 and T4; free T3 and T4 i.e. FT3 and FT4) and thyroid-stimulating hormone (TSH) levels. The median level of TBPH in the blood samples of school students was 6.6 ng/g lipid (mean 11 ng/g lipid). The frequency of detection is given with 83%. No control group was included in this investigation. The authors postulate positive/negative associations (linear trends) with the sums of blood concentrations of several chemicals via multiple linear regression analysis. No information is given on a potential activity of TBPH alone.