Registration Dossier
Registration Dossier
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EC number: 247-426-5 | CAS number: 26040-51-7
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: surveillance data
- Adequacy of study:
- supporting study
- Study period:
- 2015
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Association between serum polybrominated diphenyl ethers, new flame retardants and thyroid hormone levels for school students near a petrochemical complex, South China
- Author:
- Guo L-C et al
- Year:
- 2 018
- Bibliographic source:
- Chemosphere 202 (2018) 476-482
Materials and methods
- Endpoint addressed:
- other: blood concentrations and association to thyroid hormone levels
- Principles of method if other than guideline:
- no Guideline followed
Test material
- Reference substance name:
- Bis(2-ethylhexyl) tetrabromophthalate
- EC Number:
- 247-426-5
- EC Name:
- Bis(2-ethylhexyl) tetrabromophthalate
- Cas Number:
- 26040-51-7
- Molecular formula:
- C24H34Br4O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
In the this publication 174 school students living in a high pollution area (near a petrochemical complex) in South China (average age 10) were included to collect data and examine the influence of flame retardants on thyroid hormone (TH; serum T3 and T4; free T3 and T4 i.e. FT3 and FT4) and thyroid-stimulating hormone (TSH) levels. The median level of TBPH in the blood samples of school students was 6.6 ng/g lipid (mean 11 ng/g lipid). The frequency of detection is given with 83%. No control group was included in this investigation. The authors postulate positive/negative associations (linear trends) with the sums of blood concentrations of several chemicals via multiple linear regression analysis. No information is given on a potential activity of TBPH alone.
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