Zirconium propionate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Reason see "Supporting: SS_UCC_1957_Acute dermal rabbit": Non-GLP study similar to OECD guideline 402. However petechial hemorrhage of the lungs do raise questions on reliability of the study. Beyond this, the result does not really fit with dermal irritation studies (no mortality but skin corrossion after application of 0.5 mL propionic acid).

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC and Striegel JA

Year:

1962

Bibliographic source:

Am. Ind. Hyg. Assoc. J., 23(4), 95-107

Materials and methods

Principles of method if other than guideline:

According to Draize et al. 1944. J. Pharmacol. Exper. Therap. 82, 377

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Propionic acid

EC Number:

201-176-3

EC Name:

Propionic acid

Cas Number:

79-09-4

Molecular formula:

C3H6O2

IUPAC Name:

propionic acid

Details on test material:

- Name of test material (as cited in study report): propionic acid
- Source: no data
- Analytical purity: no data

Test animals

Species:

rabbit

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

- Weight at Test initiation: 2.5-3.5 kg

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: plastic film


REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: no data


TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data

Duration of exposure:

24 h

Doses:

no data

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

Penetration of rabbit skin was estimated by a technique closely akin to the one-day cuff method of Draize and associates (1944). Before application, the fur was clipped from the entire trunk of the animals and the substance occlusively applied under a plastic film for 24h within which time the animals were immobilized. The film was removed at the end of the application period and the animals were subsequently caged and observed for another 14d.

LD 50 and its fiducial range was estimated by the method of Thompson (Bacteriol. Rev. 1 : 115 (June 1947)) using the tables of Weils. Biometrics 8: 249 (Sept. 1952))

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

0.5 mL/kg bw

95% CL:

0.37 - 0.67

Remarks on result:

other: All deaths occurred on the day of dosing.

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

496 mg/kg bw

Remarks on result:

other: calculated (desity 0.992 mg/ml @20°C)

Mortality:

All deaths occurred on the day of dosing

Clinical signs:

other: Covered application of propionic acid to the intact skin for 24 hours also resulted in necrosis at the site of application

Gross pathology:

Necropsy of animals dying in this study revealed hemorrhage of the lungs and intestines, congested livers and kidneys