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EC number: 281-897-8 | CAS number: 84057-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Reason see "Supporting: SS_UCC_1957_Acute dermal rabbit": Non-GLP study similar to OECD guideline 402. However petechial hemorrhage of the lungs do raise questions on reliability of the study. Beyond this, the result does not really fit with dermal irritation studies (no mortality but skin corrossion after application of 0.5 mL propionic acid).
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC and Striegel JA
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 23(4), 95-107
Materials and methods
- Principles of method if other than guideline:
- According to Draize et al. 1944. J. Pharmacol. Exper. Therap. 82, 377
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Propionic acid
- EC Number:
- 201-176-3
- EC Name:
- Propionic acid
- Cas Number:
- 79-09-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- propionic acid
- Details on test material:
- - Name of test material (as cited in study report): propionic acid
- Source: no data
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Weight at Test initiation: 2.5-3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: plastic film
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: no data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Penetration of rabbit skin was estimated by a technique closely akin to the one-day cuff method of Draize and associates (1944). Before application, the fur was clipped from the entire trunk of the animals and the substance occlusively applied under a plastic film for 24h within which time the animals were immobilized. The film was removed at the end of the application period and the animals were subsequently caged and observed for another 14d.
LD 50 and its fiducial range was estimated by the method of Thompson (Bacteriol. Rev. 1 : 115 (June 1947)) using the tables of Weils. Biometrics 8: 249 (Sept. 1952))
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.5 mL/kg bw
- 95% CL:
- 0.37 - 0.67
- Remarks on result:
- other: All deaths occurred on the day of dosing.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 496 mg/kg bw
- Remarks on result:
- other: calculated (desity 0.992 mg/ml @20°C)
- Mortality:
- All deaths occurred on the day of dosing
- Clinical signs:
- other: Covered application of propionic acid to the intact skin for 24 hours also resulted in necrosis at the site of application
- Gross pathology:
- Necropsy of animals dying in this study revealed hemorrhage of the lungs and intestines, congested livers and kidneys
Applicant's summary and conclusion
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