Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-125-9 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (5.75 h) = 43 mg/L, P. putida (method similar or equivalent to DIN 38412 L 27), read across
Key value for chemical safety assessment
Additional information
There are no data available on the toxicity to aquatic microorganisms of “hydrolysis product of 3-(triethoxysilyl)propan-1-amine >0.1 - <16%" (EC no. 939-125-9). In order to fulfil the standard information requirements set out in Annex VIII, read-across from a structurally related substance ( 3-(triethoxysilyl)propan-1-amine, CAS no. 919-30-2), is conducted in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
This read-across is based on the hypothesis that the starting material, 3-(triethoxysilyl)propan-1-amine, hydrolyses rapidly in water resulting in the target substance. It can be expected that both the target and the source substance product have similar behaviour under the aqueous conditions. The target substance consists of the hydrolysis product 3-aminopropylsilanetriol and condensation products dimers, trimers and polymers of siloxanes which have similar functional groups (-O-Si- or HO-Si-). Therefore, it is considered that the target substance and 3-(triethoxysilyl)propan-1-amine are in one class of compounds and structural differences are not supposed to contribute to significant differences in activity with respect to eco- and human toxicological endpoints. The other hydrolysis product is ethanol, which is well described in the public domain to have no adverse environmental effects.
A detailed analogue approach justification is provided in the technical dossier (Please refer to IUCLID Section 13 for further information).
The toxicity of 3-(triethoxysilyl)propan-1-amine (CAS no. 919-30-2) to aquatic microorganisms has been investigated in a study by Evonik (1994). Although not specifically mentioned in the report, this test was performed according to DIN 38412 L 27 under GLP conditions. Pseudomonas putida was exposed to the test substance for 5-6 hours within a static water regime to four different test substance concentrations. Effects on bacterial respiration rate (measured as oxygen consumption) were observed, resulting in EC10 and EC50 values of 13 and 43 mg/L, respectively. It is very likely that this effect concentration reflects rather a worst case approach, as a single microorganism strain was tested individually.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
