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EC number: 939-125-9 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) > 934 mg/L, Danio rerio (EU method, C1), read across
Key value for chemical safety assessment
Additional information
There are no data available on the acute toxicity to fish of “hydrolysis product of 3-(triethoxysilyl)propan-1-amine > 0.1% - <16%
” (EC no. 939-125-9). In order to fulfil the standard information requirements set out in Annex VIII, read-across from a structurally related substance (3-(triethoxysilyl)propan-1-amine, CAS no. 919-30-2), is conducted in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.This read-across is based on the hypothesis that the starting material, 3-(triethoxysilyl)propan-1-amine, hydrolyses rapidly in water resulting in the target substance. It can be expected that both the target and the source substance product have similar behaviour under the aqueous conditions. The target substance consists of the hydrolysis product 3-aminopropylsilanetriol and condensation products dimers, trimers and polymers of siloxanes which have similar functional groups (-O-Si- or HO-Si-). Therefore, it is considered that the target substance and 3-aminopropyltriethoxysilane are in one class of compounds and structural differences are not supposed to contribute to significant differences in activity with respect to eco- and human toxicological endpoints. The other hydrolysis product is ethanol, which is well described in the public domain to have no adverse environmental effects.
A detailed analogue approach justification is provided in the technical dossier (Please refer to IUCLID Section 13 for further information).
The acute toxicity of 3-(triethoxysilyl)propan-1-amine (CAS no. 919-30-2) to fish species has been investigated in a study by Huels (1994). This test was performed according to EU Method C1. Acute Toxicity for Fish (92/69/EEC), under GLP conditions. Fishes (Brachydanio rerio) were exposed to the test substance for 96 hours within a semi-static water regime in a limit test (1000 mg/L nominal corresponding to a mean measured concentration of 934 mg/L based on carbon measurement). No further analytical dose verifications were performed. Effects were monitored every 24 hours until the end of the experiment. No mortality was reported in treatment or control groups and therefore, an LC50 (96 h) > 934 mg/L was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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