Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-125-9 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (72 h) > 1000 mg/L nominal, Scendesmus subspicatus (EU Method C.3), read across
Key value for chemical safety assessment
Additional information
There are no data available on the aquatic toxicity to algae of “hydrolysis product of 3-(triethoxysilyl)propan-1-amine > 0.1% - <16%
” (EC no. 939-125-9). In order to fulfil the standard information requirements set out in Annex VIII, read-across from a structurally related substance ( 3-(triethoxysilyl)propan-1-amine, CAS no. 919-30-2), is conducted in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.This read-across is based on the hypothesis that the starting material, 3-(triethoxysilyl)propan-1-amine, hydrolyses rapidly in water resulting in the target substance. It can be expected that both the target and the source substance product have similar behaviour under the aqueous conditions. The target substance consists of the hydrolysis product 3-aminopropylsilanetriol and condensation products dimers, trimers and polymers of siloxanes which have similar functional groups (-O-Si- or HO-Si-). Therefore, it is considered that the target substance and 3-aminopropyltriethoxysilane are in one class of compounds and structural differences are not supposed to contribute to significant differences in activity with respect to eco- and human toxicological endpoints. The other hydrolysis product is ethanol, which is well described in the public domain to have no adverse environmental effects.
A detailed analogue approach justification is provided in the technical dossier (Please refer to IUCLID Section 13 for further information).
The acute toxicity of 3-(triethoxysilyl)propan-1-amine (CAS no. 919-30-2) to algae species has been investigated in a study by Evonik (1993). This test was performed according to EU Method C.3 (Algal Inhibition test) under GLP conditions. Scenedesmus subspicatus was exposed to the test substance for 72 hours within a static water regime. Two main tests were performed with different concentrations since it was not possible to determine a NOEC in the first main test. The following nominal test substance concentrations were used: 0, 33, 67, 133, 278, 556, 1000 mg/L (main test 1); 0, 1.3, 2.5, 5.1, 10.1 mg/L (main test 2). Nominal test substance concentrations were established based on DOC measurement of the stock solution. No further analytical dose verifications were performed. Effects were monitored every 24 hours until the end of the experiment. An EC50 (72 h) > 1000 mg/L (nominal) was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
