Registration Dossier
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EC number: 939-125-9 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48 h) = 331 mg/L nominal, Daphnia magna (DIN 38412 Part 1; EG Guideline 92/69/EWG), read across
Key value for chemical safety assessment
Additional information
There are no data available on the acute toxicity to aquatic invertebrates of “hydrolysis product of 3-(triethoxysilyl)propan-1-amine > 0.1% - <16%
” (EC no. 939-125-9). In order to fulfil the standard information requirements set out in Annex VIII, read-across from a structurally related substance ( 3-(triethoxysilyl)propan-1-amine, CAS no. 919-30-2), is conducted in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.This read-across is based on the hypothesis that the starting material, 3-(triethoxysilyl)propan-1-amine, hydrolyses rapidly in water resulting in the target substance. It can be expected that both the target and the source substance have similar behaviour under the aqueous conditions. The target substance consists of the hydrolysis product 3-aminopropylsilanetriol and condensation products dimers, trimers and polymers of siloxanes which have similar functional groups (-O-Si- or HO-Si-). Therefore, it is considered that the target substance and 3-aminopropyltriethoxysilane are in one class of compounds and structural differences are not supposed to contribute to significant differences in activity with respect to eco- and human toxicological endpoints. The other hydrolysis product is ethanol, which is well described in the public domain to have no adverse environmental effects.
A detailed analogue approach justification is provided in the technical dossier (Please refer to IUCLID Section 13 for further information).
The acute toxicity of 3-(triethoxysilyl)propan-1-amine (CAS no. 919-30-2) to aquatic invertebrate species has been investigated in a study by Evonik (1993). This test was performed according to DIN 38412 Part 1; EG Guideline 92/69/EWG under GLP conditions. Daphnia magna was exposed to the test substance for 48 hours within a static water regime at the following nominal test substance concentrations: 0, 8.7, 16.4, 28.4, 54.7, 94.0, 174.9, 306.0, 546.5, and 983.7 mg/L. Nominal test substance concentrations were established based on DOC measurement of the stock solution. No further analytical dose verifications were performed. Effects were monitored every 24 hours until the end of the experiment. An EC50 (48 h) of 331 mg/L (nominal) was determined.
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