Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 250-439-9 | CAS number: 31027-31-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Neither with nor without S9-mix p-isopropylphenyl isocyanate showed mutagenic properties up to a concentration of 1500 µg/plate. With a concentration of 3000 µg/plate percipitation occurs and with 5000 µg/plate (but not with 10 to 1000 µg/plate) in a concentration range finding study on TA 98 and TA 100 a bacteriotoxic effect was seen.
Short description of key information:
in vitro:
Ames test: negative
Cytogenetic assay: no data
mammalian cell gene mutation test: no data
in vivo:
no data
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
from the available data a classification is not justified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
