Registration Dossier
Registration Dossier
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EC number: 250-439-9 | CAS number: 31027-31-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: cited in BG 249 (Hoechst study)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 405
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-isopropylphenyl isocyanate
- EC Number:
- 250-439-9
- EC Name:
- p-isopropylphenyl isocyanate
- Cas Number:
- 31027-31-3
- Molecular formula:
- C10H11NO
- IUPAC Name:
- 1-isocyanato-4-(propan-2-yl)benzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: conjunctival sac
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- 0.1 ml of test substance was applied into the conjunctival sac and revomed after 24 h
- Doses:
- 0.1 ml of test substance
- No. of animals per sex per dose:
- 3 total
- Control animals:
- not specified
Results and discussion
- Mortality:
- 2 out of 3 animals died during post-observation period
- Clinical signs:
- noisy breathing, severe dyspnoae
- Body weight:
- weight reduction
- Gross pathology:
- stomach filled with gas and pulp, strong reddened intestine filled with greenish liquid, brightened and uneven liver
Any other information on results incl. tables
during an eye irriation study according OECD 405, 2 out of 3 animals died on day 4 and day 8 after application of test substance
Applicant's summary and conclusion
- Executive summary:
method: eye irritation study according OECD 405
result: 2 out of 3 animals died on day 4 and day 8
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