Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Amount / concentration applied:
- TEST MATERIAL
- Concentration: 50% (aqueous grinding) - Duration of treatment / exposure:
- 20h (dorsal)
- Observation period:
- observation 24h and 8 days after treatment
Results and discussion
In vivo
Results
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid was not irritating in the in vivo skin irritation test.
- Executive summary:
In a primary dermal irritation study rabbits were dermally exposed to 50% 3-hydroxy-2-methylquinoline-4-carboxylic acid (vehicle: water) for 20 hours (dorsal).
Animals were observed 24 hours as well as 8 days after application.
Only yellow substance remnant was observed in animals with 20h dorsal treatment.
In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid is not a dermal irritant.
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