Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 2-30% - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 470 mg/kg bw
- Based on:
- act. ingr.
- Clinical signs:
- slight apathy, partly dyspnoea, at high doses twitching and spring cramps
- Gross pathology:
- intraabdominal substance precipitation
Applicant's summary and conclusion
- Conclusions:
- The intraperitoneal LD50 of 3-hydroxy-2-methylquinoline-4-carboxylic acid in mice was ca. 470 mg/kg bw.
- Executive summary:
In an acute toxicity study, mice were given a single dose of 3-hydroxy-2-methylquinoline-4-carboxylic acid in aqueous suspension with carboxymethyl cellulose by intraperitoneal administration and were observed for 7 days.
During the observation period, clinical signs were slight apathy, partly dyspnoea, at high doses twitching and spring cramps. During gross pathology, intraabdominal substance precipitation was observed.
Intraperitonal LD50 (mice) ca. 470 mg/kg bw
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