Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effect of neurohypophysectonomy on antidiuretic activity of substituted 3-hydroxy chinoninic acids in the rat
- Author:
- Maren TH, Bodian D
- Year:
- 1 951
- Bibliographic source:
- American Journal Physiology 164, 49-60 (1951)
- Reference Type:
- publication
- Title:
- The reflex respiratory and circulatory actions of some cinchoninic acid derivatives and a number of unrelated compounds
- Author:
- Walker HA, Wilson S, Farrar C, Richardson AP
- Year:
- 1 952
- Bibliographic source:
- J Pharmacology Experimental Therapeutics 104, 211-218 (1952)
Materials and methods
- Principles of method if other than guideline:
- The antidiuretic effect of 3-hydroxy cinchoninic acids was examined in rats and the reflex respiratory and circulatory actions of cinchoninic acid derivatives was studies in dogs and cats.
- GLP compliance:
- no
- Endpoint addressed:
- other: antidiuretic, respiratory and circulatory effects
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
Constituent 1
Test animals
- Species:
- other: rat, dog, cat
Administration / exposure
- Route of administration:
- intravenous
Results and discussion
- Details on results:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid has antidiuretic and reflex respiratory/circulatory effects (apnea, fall of blood pressure, bradycardia).
Applicant's summary and conclusion
- Executive summary:
3-hydroxy-2-methylquinoline-4-carboxylic acid has antidiuretic and reflex respiratory/circulatory effects (apnea, fall of blood pressure, bradycardia).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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