Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- TEST MATERIAL
- Concentration: 50% (aqueous grinding) - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- none
- Clinical signs:
- none
- Gross pathology:
- none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of 3-hydroxy-2-methylquinoline-4-carboxylic acid in rats was > 2500 mg/kg bw.
- Executive summary:
In an acute toxicity study, rats were given a single dose of 50% 3-hydroxy-2-methylquinoline-4-carboxylic acid (aqueous grinding) at a dose of 2500 mg/kg bw and were observed for 14 days.
During the observation period, no death occurred and no clinical or gross pathological signs were observed.
Dermal LD50 (rats) > 2500 mg/kg bw
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