Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Endpoint summary
Administrative data
Description of key information
-skin irritation: RL4; pre-GLP; rabbit; observation time: 8 days; only yellow substance remnant was observed in animals with 20h dorsal treatment.
-eye irritation: RL4; pre-GLP; rabbit; observation time: 8 days; slight irritating effects (conjunctival redness) 1 hour after application, slight edema and pastel green substance remnants; slight conjunctival redness up to 24 h after application; all effects fully reversed after 8 days.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Amount / concentration applied:
- TEST MATERIAL
- Concentration: 50% (aqueous grinding) - Duration of treatment / exposure:
- 20h (dorsal)
- Observation period:
- observation 24h and 8 days after treatment
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid was not irritating in the in vivo skin irritation test.
- Executive summary:
In a primary dermal irritation study rabbits were dermally exposed to 50% 3-hydroxy-2-methylquinoline-4-carboxylic acid (vehicle: water) for 20 hours (dorsal).
Animals were observed 24 hours as well as 8 days after application.
Only yellow substance remnant was observed in animals with 20h dorsal treatment.
In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid is not a dermal irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- non information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 50 mg - Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- 1 hour, 24 hours, 8 days after application
- Remarks on result:
- other:
- Remarks:
- slight irritation observed up to 24 hours after application; fully reversible within 8 days
- Irritant / corrosive response data:
- 1 hour after application: slight redness in mucous membrane, slight edema and pastel green substance remnants; 24 hours after application: slight redness in mucous membrane; 8 days after application: no effects observed (former effects fully reversed). The same effects profile was obtained with talcum.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid was not irritating to the eyes.
- Executive summary:
In a primary eye irritation study, 3-hydroxy-2-methylquinoline-4-carboxylic acid was applied to the eye in rabbits. Animals then were observed for 8 days. Slight irritating effects were observed 1 hour after application by observation of slight conjunctival redness, slight edema and pastel green substance remnants. 24 hours after application, slight conjunctival redness was still observed. 8 days after application, no effects were observed (former effects fully reversed). The same effects profile was obtained with talcum.
In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid is not an eye irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin irritation
Based on available data, the test substance does not need to be classified for skin irritation according to regulation (EC) 1272/2008.
Eye irritation
Based on available data, the test substance does not need to be classified for eye irritation according to regulation (EC) 1272/2008.
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