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EC number: 219-948-3
CAS number: 2580-77-0
Clinical Observations, Body Weight and Mortality Data –
Preliminary Screening Test
Concentration(% w/w) indimethyl formamide
Body Weight (g)
0= No signs of systemic toxicity
Skin Irritation – Preliminary Screening Test
Local Skin Irritation
Measurement of Ear Thickness and Mean Ear Thickness Changes –
Preliminary Screening Test
Ear Thickness Measurement (mm)
overall mean (mm)
overall mean ear thickness change (%)
na= Not applicable
per Minute, Disintegrations per Minute/Node and Stimulation Index
dpm = Disintegrations per minut
a = Disintegrations per minute/node obtained by dividing
the disintegrations per minute value by 8 (total number of lymph
b = Stimulation Index of 3.0 or greater indicates a
na = Not applicable
A study was performed to assess the skin sensitization potential
of the test item in the CBA/Ca strain mouse following topical
application to the dorsal surface of the ear.
Following a preliminary screening test in which no clinical signs
of toxicity were noted at aconcentration of 50% w/w, this concentration
was selected as the highest dose investigated in the main test of the
Local Lymph Node Assay. Three groups, each of four animals, were treated
with 50 µL (25 µL per ear) of the test item as asolutionindimethyl
formamideat concentrations of 50%, 25% or 10% w/w. A further group
offour animals was treated withdimethyl formamidealone.
The Stimulation Index expressed as the mean radioactive
incorporation for each treatment group divided by the mean radioactive
incorporation of the vehicle control group are as follows:
Concentration (%w/w) indimethyl formamide
The test item was considered to be a non-sensitizer under the
conditions of the test.
The test item does not meet the criteria for classification
according to the Globally Harmonized Classification System and to the
Regulation (EC) No 1272/2008, relating to the Classification, Labelling
and Packaging of Substances and Mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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