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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
The study was conducted between 09 April 2006 and 21 April 2006
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
Sponsor's identification: BHES-100X
Description: white solid block
Batch number: 5K0718-CC
Date received: 21 January 2006
Storage conditions: room temperature, over silica gel, in the dark



Key result
Test no.:
#5
Temp.:
25 °C
Vapour pressure:
< 0.001 Pa

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25°C.

Run 5 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 12°C (285.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of -1500 K is imposed upon it.

The value of -1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25°C gave a vapour pressure of 7.769 x 10^-4 Pa which has been taken as a maximum for this material.

The test material did not change in appearance under the conditions used in the determination.

Conclusions:
The vapour pressure of the test material has been determined to be less than 7.8 x 10^-4 Pa at 25 °C.
Executive summary:

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25 °C. Testing was conducted using Method A4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67 /548/EEC). The vapour pressure of the test material has been determined to be less than 7.8 x 10^-4 Pa at 25 °C.

Description of key information

The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis used to calculate the vapour pressure at 25 °C. Testing was conducted using Method A4 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67 /548/EEC). The vapour pressure of the test material has been determined to be less than 7.8 x 10^-4 Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:
0.001 Pa
at the temperature of:
20 °C

Additional information