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EC number: 219-948-3
CAS number: 2580-77-0
The study was performed to assess the acute oral toxicity of the test
material following a single oral administration in the Sprague-Dawley CD
strain rat. The method was
designed to meet the requirements of the following:
• OECD Guidelines for the Testing of Chemicals No. 423 "Acute Oral
Toxicity- Acute Toxic
Class Method" (adopted 1 7 December 2001)
• Method B1 tris Acute Toxicity (Oral) of Commission Directive 2004/73/EC
A group of three fasted females was treated with the test material at a
dose level of 2000 mg/kg bodyweight. This was followed by a further
group of three fasted females at the same dose level.
The test material was administered orally as a solution in distilled
water. Clinical signs and bodyweight development were monitored during
the study. All animals were subjected to gross necropsy.
Mortality: There were no deaths.
Clinical Observations: There were no signs of systemic toxicity.
Bodyweight: All animals showed expected gains in bodyweight over
the study period.
Necropsy: No abnormalities were noted at necropsy.
The acute oral median lethal dose (LDso) of the test material in the
female Sprague-Dawley CD strain rat was estimated to be greater than
2500 mg/kg bodyweight (Globally Harmonised Classification System -
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