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EC number: 203-095-9
CAS number: 103-28-6
The dermal irritation potential of test
article was determined according to the OECD 439 test guideline followed
for this study. The MatTek EpiDerm™ model was used to assess the
potential dermal irritation of the test article by determining the
viability of the tissues following exposure to the test article via MTT.
The objective of this study was to assess
the dermal irritation potential of test article. Tissues were exposed to
test article and controls for ~one hour, followed by a 42 hour
post-exposure recovery period. The viability of each tissue was
determined by MTT assay. The MTT data show the assay quality controls
were met, as the OD of the negative control tissues was between 1.195
and 1.430. Also, the positive control, 5% sodium dodecyl sulfate (SDS),
reduced tissue viability to 4.5% of negative control and the standard
deviation (SD) calculated from individual percent tissue viabilities of
the test article exposed replicates was 9.6 passing the acceptance
The Mean % tissue viability compared to
negative control (n=3) of the test substance was determined to be 53.3%.
Hence, under the experimental test conditions it was concluded that test
substance was considered to be not irritating to the human skin and
being classified as “Not Classified'' as per CLP Regulation.
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