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EC number: 203-095-9
CAS number: 103-28-6
The ocular irritation potential of
test article was determined according to the OECD 492 test guideline
followed for this study. The MatTek EpiOcular™ model was used to assess
the potential ocular irritation of the test articles by determining the
viability of the tissues following exposure to the test article via MTT.
The objective of this study was to
assess the ocular irritation potential of test article. Tissues were
exposed to liquid test article and controls for ~30 minutes, followed by
a ~12 minute post-soak and approximately 2 hour recovery after the
post-soak. The viability of each tissue was determined by MTT assay.
The MTT data show the assay quality controls were met, as the OD of the
negative control tissues was between 0.981 and 1.284 in run 1. Also, the
positive control, methyl acetate, reduced tissue viability to be 22.1%
(for 30 minute exposures with liquids) of negative control in run one
and the standard deviation (SD) calculated from individual percent
tissue viabilities of the test article exposed replicates was 9.6
passing the acceptance criteria. The mean % tissue viability of test
substance was determined to be 37.9%.
Hence, under the experimental test
conditions it was concluded that test substance is considered to be an
eye irritant and being classified as “Irritating to eyes in Category 2”
as per CLP Regulation.
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