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EC number: 203-095-9
CAS number: 103-28-6
A subacute repeated dose oral toxicity
study was conducted to evaluate the toxic effects of repeated
administration of the test chemical in male and female Sprague-Dawley
rats by gavage. The test chemical was administered to 6
animals/sex/species with vehicle as corn oil at doses of 0, 250, 500 and
1000 mg/kg/bw/day for 28 days. All rats of 250, 500 and 1000
mg/kg/bw/day dose group survive though-out the study, the test
chemical have no effect on mortality. Blood samples for Clinical
Biochemistry and Haematology were collected. No abnormalities occurred
that could be directly attributed to test chemical treatment. Although
significant change in relative weights of liver, ovaries and lungs of
female were observed in 1000 mg/kg/bw/day dose groups. No treatment
related gross pathological or histological changes were seen and
findings were not considered to be test chemical dependent and hence
considered to be of no toxicological importance. Therefore the No
Observed Adverse Effect Level (NOAEL) for repeated dose toxicity study
was considered to be 1000 mg/kg/bw/day in male and female Sprague-Dawley
rats when exposed to the test chemical by oral route for 28 days.
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