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EC number: 203-095-9
CAS number: 103-28-6
Mortality / number of animals treated
Summary of acute toxicity studies
NO. animals/dose group
Ina acute oral toxicity study, male
and female rats were treated with test chemical in the concentration of
2510, 3160, 3980 or 5000 mg/kg orally by gavage and observed for 14
days. In preliminary studies, dose levels of 316, 1260 and 5000 mg/kg
resulted in mortality in 0/2, 0/2 and 2/2 rats from low to high dose. In
main study, all animals were died at 5000 mg/kg bw, 9 animals died at
3980 mg/kg bw, 6 animals died at 3160 mg/kg bw and 4 animals died at
2510 mg/kg. Sedation and tremors were observed in treated rats. No gross
pathological alterations were observed in treated male and female rats
at necropsy. Therefore, LD50 was considered to be 2850 mg/kg bw
(2252-3608 mg/kg) when male and female rats were treated with test
chemical orally by gavage.
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