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EC number: 232-455-8
CAS number: 8042-47-5
A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C15 through C50.
a 90-day dermal toxicity study,80SUS
white mineral oil was applied to the clipped skin of 10
Sprague-Dawley rats/sex/dose at dose levels of 0, 125, 500, or 2000
mg/kg bw/day during a 90-day period.
of the test material to the skin produced skin irritation at all dose
levels, which included erythema, flaking of the skin, and scabs at the
site of test material application. Male
and female rats dosed at 500 and 2000 mg/kg bw/day showed a decrease
in body weight when compared to the controls, and was a statistically
significant decrease for males exposed to 500 and 2000 mg/kg bw/day
and females exposed to 2000 mg/kg bw/day. Urinalysis
and haematological effects were of doubtful toxicological significance. There
were no other compound-related effects on mortality, clinical signs,
food consumption, organ weights, clinical chemistry. The
NOAEL for local effects is < 125 mg/kg based on skin irritation, while
the NOAEL for systemic effects is greater than or equal to 2000 mg/kg,
absence of significant toxicological findings of concern.
study received a Klimisch score of 1 and is classified as reliable
without restrictions because it was carried out according to OECD test
guideline 411 and GLP.
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