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EC number: 232-455-8
CAS number: 8042-47-5
A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C15 through C50.
a one-generation reproduction study, white mineral oil was administered
dermally to Sprague-Dawley rats (10/dose for males, 20/dose for females)
at dose levels of 0, 125, 500, or 2000 mg/kg bw/day at a frequency of 5
days/week during premating and daily during gestation (for females).
No mortality was observed in any
treatment groups. No treatment-related changes in body weight gain or
food consumption were observed in the females of the parental
generation. No adverse effects were noted in the number of implantation
sites per dam, litter size, or length of gestation in treated animals.
Treatment-related clinical signs included erythema, scabs, and flaking
at application site at all dose levels. No signs of gross toxicity were
observed at necropsy. The
parental systemic NOAEL is greater than or equal to 2000 mg/kg bw/day
for females. Data on males were not provided in this study report.
The offspring exhibited no significant
differences in body weight gain, eyelid disjunction, righting reflex, or
viability in treated groups versus control. No treatment-related signs
of gross pathology were noted at necropsy. The
offspring NOAEL is greater than or equal to 2000 mg/kg bw/day.
This study received a Klimisch score of 2
and is classified as reliable with restrictions because, although it
closely follows OECD Guideline 415, no GLP statement was provided in the
study report and only data on pregnant females and pups were provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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