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EC number: 232-455-8
CAS number: 8042-47-5
A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C15 through C50.
this comparative pathology review, the authors examined the microscopic
effects that occurred in F-344 rats following oral ingestion of white
mineral oils and compared them with the findings in Sprague-Dawley rats
and with the lesions reported in man following prolonged ingestion of
large quantities of mineral oil.
comparison revealed that the response in the F-344 rat was in contrast
to that in the Sprague-Dawley since at comparable dose levels no lesions
were observed in the Sprague-Dawley rat. The authors also concluded
that the lesion observed in humans (lipogranulomas) following ingestion
of mineral oil was different to that seen in F-344 rats.
was concluded that the majority, if not all, of the lesions seen in the
F-344 rat were of no significance for humans.
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