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EC number: 232-455-8
CAS number: 8042-47-5
A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C15 through C50.
In a primary eye irritation study [Klimisch
score = 1], the right eye of 12 male New Zealand White rabbits was dose
with 0.1 mL of undiluted highly refined base oil. In 6 of the animals,
the treated eye was flushed with water after 20 to 30 seconds of
treatment. In the remaining 6 animals, the treated eye was not flushed.
The left eye of each animal served as the untreated control.
Observations of ocular lesions were made at 24, 48, 72 hours, day 4, day
5, and day 7 after dosing. The eyes were examined and scored according
to the Draize system. Flourescein examination of all eyes was made on
A very mild irritation occurred in one
rabbit in the rinsed at 24 hours, but was completely reversible by 48
hours. A very mild irritation occurred in a different rabbit in the
rinsed group at 48 hours, but was completely reversible by 4 days. A
very mild irritation occurred in one rabbit in the unrinsed group at 24
hours, but was completely reversible by 48 hours. A second rabbit in the
unwashed group exhibited a very mild irritation at 48 hours, but was
completely reversible by 72 hours. Under the conditions of this study,
the mean unwashed cornea and iris scores (24-72 hours) were both 0.0.
The mean unwashed conjunctivae score (24-72 hours) was 0.22. The test
material is considered not irritating to the eye.
This study received a Klimisch score of 1
because it was carried out according to guideline study OECD TG 405.
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