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EC number: 232-455-8
CAS number: 8042-47-5
A highly refined petroleum mineral oil consisting of a complex combination of hydrocarbons obtained from the intensive treatment of a petroleum fraction with sulfuric acid and oleum, or by hydrogenation, or by a combination of hydrogenation and acid treatment. Additional washing and treating steps may be included in the processing operation. It consists of saturated hydrocarbons having carbon numbers predominantly in the range of C15 through C50.
Summary of challenge 2 scores
Test and Control Group
F-52-01 Challenge Control
Positive Control 0.2% DNCB
4.2 to 4.4
0.2% DNCB Challenge Control
In a skin sensitisation study, male guinea
pigs were used in irritation, induction, and challenge tests to
determine if Highly refined base oil is a delayed dermal sensitizer.
During the induction phase, 0.5 mL of undiluted test article (F-52-01
test group; n=10) or 0.3% DNCB in 80% ethanol/water (positive control
test group; n=10) was applied to a shaved area along the dorsal midline
and removed after 6 hours. This procedure was performed once a week
every three weeks. Fourteen days after the last induction dose was
applied, the positive control test group (n=10), the F-52 -02 test group
(n=10), the F-52 -01 challenge control group (n=4), and the 0.2% DNCB
challenge control group (n=2) were administered either 0.5 mL of
undiluted White mineral oil [F-52 -01] or 0.2% DNCB in 80% ethanol/water
on naive test sites. The patches were removed after 6 hours of exposure
and the challenge sites were scored at 24 and 48 hour post-application.
No significant increased response to white
mineral oil was observed at challenge treatment 2 compared to induction
treatment. The response of the treatment animals was similar to the
response of the F-52-01 challenge control group. Based on these findings
and under the conditions of this study, Highly refined base oil is not a
delayed contact dermal sensitizer. DNCB induced a delayed contact
sensitizing response in challenge treatment 2. The positive control
group had response grades and a severity index that was higher than the
DNCB challenge control group, which substantiated the positive control
This study received a Klimisch score of 1and
is classified as reliable without restriction because it was carried out
according to or similar to OECD TG 406.
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