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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study based on national standard, acceptable for assessment, but with limited documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Code of Federal Regulation - 16 CFR, Part 1500.3
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
25640-78-2 + 69009-90-1
IUPAC Name:
25640-78-2 + 69009-90-1
Constituent 2
Reference substance name:
(1-methylethyl)-1,1'-biphenyl + 1,1'-Biphenyl, bis(1-methylethyl)-
IUPAC Name:
(1-methylethyl)-1,1'-biphenyl + 1,1'-Biphenyl, bis(1-methylethyl)-
Details on test material:
- Name of test material (as cited in study report): MIPB, isopropyl biphenyl
- Substance type: organic
- Physical state: liquid
- Lot-No. A-36477

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Bunnyville Farms, littletown, Pennsylvania
- Age at study initiation: no data
- Weight at study initiation: 2.3 - 3.1 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: one square inch (6.25 cm²); 2/4 animals per group, abraded or nonabraded skin
- Type of wrap if used: gauze patch wrapped with nonadsorbant binder.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with tap water

Duration of exposure:
24 h
Doses:
4640 and 6000 mg/kg bw
No. of animals per sex per dose:
4 per dose, in total 8 animals
Control animals:
not required
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
not applicable

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality, except
1/4 animals (group 4640 mg/kg) on day 2, but considered unrelated to the treatnment and was replaced.
Clinical signs:
other: Depression in all animals but 1/4 in the 6000-mg/kg group, anorexia in 3/4 and phonation in 1/4 animals in the 4640-mg/kg group.
Gross pathology:
1/4 animals jelly-like material in the intestines,
no other particular findings in any of the other animals.
Other findings:
Signs of dermal irritation observed in all of the rabbits at the 4640 mg/kg level included slight to moderate erythema and slight desquamation.
At the 6000 mg/kg level, slight to moderate erythema and slight desquamation occurred in all of the animals with the findings being of longer duration in the abraded site animals. Edema occurred on Day 1 in one intact site animal.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU