Registration Dossier
Registration Dossier
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EC number: 247-156-8 | CAS number: 25640-78-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment, only meeting abstract available; study subject does not correspond to REACH information requirements
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- After intraperitoneal application of single or multiple doses of gamma-methyl-4-phenylmandelic acid, a major metabolite of 4-isopropylbiphenyl, development of renal lesions was investigated. Renal lesions were also observed after application of 4-isopropylbiphenyl.
- GLP compliance:
- no
- Remarks:
- pharmacological programme
Test material
- Reference substance name:
- 4-isopropylbiphenyl
- EC Number:
- 230-420-1
- EC Name:
- 4-isopropylbiphenyl
- Cas Number:
- 7116-95-2
- Molecular formula:
- C15H16
- IUPAC Name:
- 4-Isopropylbiphenyl
- Details on test material:
- - Name of test material (as cited in study report): 4-isopropylbiphenyl major metabolite, gamma-4-phenylmandelic acid
- no further information
Constituent 1
Test animals
- Species:
- other: rats and dogs
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- single of multiple doses of 250 mg/kg bw
- No. of animals per sex per dose:
- no data
Results and discussion
Effect levels
- Remarks on result:
- other: Increase in relative kidney weights; progressive alterations in function and structure of the kidney; time sequential changes of cortical tubules (4-8 h), collecting tubules (8-24 h) and papilla (24-48h)
- Mortality:
- no data
- Clinical signs:
- Increase in urine volume, serum creatinine, blood urea nitrogen, urine glutamic-oxalacetic transaminase, relative kidney weights, and decrease in urine specific gravity
- Gross pathology:
- Progressive alterations in function and structure of the kidney: papillary edema, dillated collecting tubules, degeneration and necrosis; dillated tubules contained precipitated proteins and minerals
- Other findings:
- - Histopathology: time sequential changes of cortical tubules (4-8 h), collecting tubules (8-24 h) and papilla (24-48h)
- Potential target organs: kidney
Applicant's summary and conclusion
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