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EC number: 225-533-8
CAS number: 4904-61-4
The analytically determined mean concentrations of 1,5,9-cyclododecatriene
were 10 ± 0.27, 25 ± 0.33, and 67 ± 1.9 ppm for the 10, 25,
and 67 ppm exposure levels, respectively. The 1,5,9-cyclododecatriene
aerosol generated in the 67 ppm chamber was considered to be respirable
in rats. The mass median aerodynamic diameter (MMAD) measurement was 2.6
μm, with 13-56% of the particles less than 1 μm, 35-89% of the
particles less than 3 μm, and 66-99% of the particles less than 10
μm. Chamber airflow, oxygen concentration, temperature, and
humidity were 59-62 L/min, 21%, 22-27ºC, and 27-67% respectively.
Female rats were exposed to 1,5,9 -cyclododecatriene aerosol at
10, 25 and 67 ppm (corresponding to 67.5, 169 and 452 mg/m3
respectively) from gestation day 6 to day 20. Observations for
morbidity and mortality were made daily. Body weights, food consumption,
and individual clinical signs were recorded. Females were euthanized on
GD 21 and the organs of the thoracic and abdominal cavities were examined
for gross pathologic changes. The intact and empty uterine weights were
recorded to calculate maternal body weight adjusted to exclude the
products of conception. The corpora lutea count for each ovary of dams
fetuses was recorded. For each female with visible implants, the
type (live and dead fetuses, and resorptions) and their relative
positions were recorded. The uterus of each apparently “nonpregnant” rat
was stained to detect very early resorptions. The body weight, sex, and
external alterations for each fetus were recorded. For each litter, the
first live fetus and every other live fetus thereafter were examined for visceral
alterations. The heads of decapitated fetuses were fixed, examined, and
alterations were recorded. The remaining fetuses were euthanized.
Skeletal alterations were recorded for all live fetuses.
Maternal toxicity was observed in this study, clinical
observations, a decreased of bodyweight gain and food consumption were
observed at 25 and 67 ppm.
There were no mortalities or early deliveries observed at any dose
level. There were no compound-related effects on mean number of
corpora lutea, implantations, resorptions, live fetuses, or fetal sex
ratio at any exposure level. There was no evidence of compound-related
embryolethality at any exposure level tested.
No evidence of developmental toxicity was observed at 10 and 25
ppm. The only evidence of developmental toxicity was a significant
reduction in mean fetal weight, and a concomitant increase in the
incidence of delayed skeletal ossification at 67 ppm.
The NOAEL for maternal toxicity was 10 ppm (67.5 mg/m3), based on
decrease of bodyweight and food consumption at 25 ppm. Developmental
toxicity was observed at 67 ppm, the NOAEL for developmental toxicity
was 25 ppm (169 mg/m3). Therefore, the results of this study indicate
that 1,5,9-cyclododecatriene is not likely to be uniquely toxic to the
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