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Short-term toxicity to fish

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Description of key information

The performance of a study on the short-term toxicity to fish is not justified.

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According to REACH Regulation (Annex VIII, 9.1.3, column 2), the study on the acute toxicity of fish does not need to be done if there are mitigating factors indicating that aquatic toxicity is unlikely to occur. In reliable experimental toxicity studies on toxic effects of diethyl carbonate to aquatic invertebrates (48 h EC50 >100 mg/L) and algae (72 h EC50>100 mg/L based on nominal concentrations each) an EC50 value could not be retrieved up to the highest test concentration applied.

Further experimental test results were reported for the acute toxicity of the structurally related carbonate ester dimethyl carbonate on Leuciscus idus: NOEC=1000 mg/L (study conducted acc. to OECD guideline 203; reliability not assignable).

The calculation of the acute toxicity of diethyl carbonate to fresh and marine water fish via ECOSAR v1.00 yielded 96 h LC50 values ranging from 45.1 to 419.4 mg/L. For adverse effects to different freshwater fish (Danio rerio, Oncorhynchus mykiss) after exposure to the structurally related carbonate esters dimethyl carbonate (DMC) and ethylmethyl carbonate (EMC), the QSAR Toolbox 3.1.0.21 predicts EC/LC50 values of > 100 mg/l (mortality, abnormal behaviour) for each of the substances, indicating a very low toxicity potential. Whereas most of the experimental as well as calculated values cited here, have to be regarded as not assignable as far as their reliability is concerned, the reported results clearly support the findings of daphnia and algal studies, that diethyl carbonate is of very low toxicity on aquatic organisms. Therefore, with respect to animal welfare, the performance of an acute fish study is assumed to be not justifiable.