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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1966
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Untersuchungen zur Toxikologie von Diaethylcarbonat
Author:
Bornmann G & Loeser A
Year:
1966
Bibliographic source:
Arch Toxicol 22, 98-114

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
see below
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
Purity: > 99.5%

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
Weight at study initiation: 200-340 g
Housing: individually
Diet: ad libitum
Water: ad libitum

ENVIRONMENTAL CONDITIONS
Temperature (°C): 26-28

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Details on oral exposure:
Concentration in vehicle: 60 % (w/v)
Doses:
22-37 mL/kg
No. of animals per sex per dose:
5 m / 5 f
Control animals:
not specified
Details on study design:
Duration of observation period following administration: up to 10 days
Necropsy of survivors performed: no data
Other examinations performed: clinical signs
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 15 000 mg/kg bw
Mortality:
yes, but not further specified
Clinical signs:
predominant sign of toxicity was narcosis
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
In male and female Wistar rats a LD50 value of > 15000 mg/kg bw was reported. The predominant sign of toxicity was narcosis.
Executive summary:

In male and female Wistar rats a LD50 value of > 15000 mg/kg bw was reported. The predominant sign of toxicity was narcosis.