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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Unpublished study report cited in a peer-reviewed publication

Data source

Reference
Reference Type:
secondary source
Title:
Diaethylcarbonat - Toxikologische Untersuchungen (unpublished report)
Author:
Bayer AG
Year:
1970
Bibliographic source:
BG Chemie (1994) Toxicological Evaluations 7. Potential Health Hazards of Existing Chemicals. Springer Verlag

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
dynamic inhalation apparatus
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
aerosol dispenser: not specified
Remarks:
migrated information: aerosol
Details on test material:
no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
Weight at study initiation: 160-200 g

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
clean air
Details on inhalation exposure:
Exposure apparatus: dynamic inhalation
Analytical verification of test atmosphere concentrations:
yes
Remarks:
not further specified
Duration of exposure:
7 h
Concentrations:
not further specified
No. of animals per sex per dose:
In total 20 m and 20 f in study
Control animals:
not specified
Details on study design:
not further specified
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1 268 mg/m³ air (analytical)
Exp. duration:
7 h
Remarks on result:
other: f: >1268 mg/m3; m: >1830 mg/m3
Mortality:
no
Clinical signs:
other: none
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
In Wistar rats, the 7 h LC50 in females was >1268 mg/m3 and in males >1830 mg/m3. The treatment caused no signs of toxicity or irritant effects.
Executive summary:

In Wistar rats, the 7 h LC50 in females was >1268 mg/m3 and in males >1830 mg/m3. The treatment caused no signs of toxicity or irritant effects.