Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Unpublished study report cited in a peer-reviewed publication

Data source

Reference
Reference Type:
secondary source
Title:
Bericht ueber die Pruefung von Diaethylcarbonat auf primaere Hautreizung (unpublished report)
Author:
Bayer AG
Year:
1981
Bibliographic source:
BG Chemie (1994) Toxicological Evaluations 7. Potential Health Hazards of Existing Chemicals. Springer Verlag

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
not further specified

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
Weight at study initiation: ca. 2300 g

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped intact or scarified skin
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 uL
Duration of treatment / exposure:
24 h
Observation period:
up to 72 h
Number of animals:
6 m
Details on study design:
not further specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
other: no details reported

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The treatment gave no indications for skin irritation
Executive summary:

Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 404. The treatment gave no indications for skin irritation.