Registration Dossier
Registration Dossier
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EC number: 203-311-1 | CAS number: 105-58-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Unpublished study report cited in a peer-reviewed publication
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: ca. 2300 g
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped intact or scarified skin
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 uL
- Duration of treatment / exposure:
- 24 h
- Observation period:
- up to 72 h
- Number of animals:
- 6 m
- Details on study design:
- not further specified
- Irritation parameter:
- overall irritation score
- Remarks on result:
- other: no details reported
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The treatment gave no indications for skin irritation
- Executive summary:
Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 404. The treatment gave no indications for skin irritation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Unpublished study report cited in a peer-reviewed publication
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Weight at study initiation: ca. 2300 g
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 100 uL
- Duration of treatment / exposure:
- not further specified
- Observation period (in vivo):
- up to 8 days
- Number of animals or in vitro replicates:
- 6 m
- Details on study design:
- TOOL USED TO ASSESS SCORE: ophthalmoscope
- Irritation parameter:
- overall irritation score
- Remarks on result:
- other: no details reported
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The treatment gave no indications for eye irritating properties
- Executive summary:
Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 405. The treatment gave no indications for eye irritation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 404. The treatment gave no indications for skin irritation.
Diethyl carbonate was tested in rabbits in a study equivalent or similar to OECD Guideline 405. The treatment gave no indications for eye irritation.
Justification for classification or non-classification
As diethyl carbonate showed no skin irritation and eye irritation, no classification according to EU and GHS criteria is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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