Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: expert statement
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: 1b Comparable to guideline study

Data source

Reference
Reference Type:
other: expert statement
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
The attached Toxicokinetic Assessment is meant to fulfill the requirement as defined in the REGULATION (EC) No 1907/2006 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 18 December 2006 requests in Annex VIII, point 8.8.1:
"Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from therelevant available information."
fulfills this
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
The relevant available data on 2-Propanol, 1,1'-[[3-[(3-aminopropyl)amino]propyl]imino]bis-, N-tallow alkyl derivs. was analyzed to assess its potential toxicokinetic behaviour. The UVCB consists of ca. 50 different compounds. Most of the constituents are n-alkane-dipropylene triamines that are partly or fully propoxylated and contain primary, secondary or tertiary amine groups which are positively charged at in the physiological pH range. Overall the absorbance is expected to be low, while the metabolisation of amines common reactions of xenobiotic metabolism. Therefore a tendency for bioaccumulation is not expected. Metabolites will be excreted both via urine and bile (feces) depending on the size and charge of the molecules.