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EC number: 307-276-4 | CAS number: 97592-79-5
Table 1: Mortality at the 500 and 2000 mg/kg bw dose-levels
Table 2: Bodyweight of male animals dosed with 500 mg/kg bw
Table 3: Bodyweight of female animals dosed with 500 mg/kg bw
Table 4: Bodyweight of male animals dosed with 2000 mg/kg bw
Table 5: Bodyweight of female animals dosed with 2000 mg/kg bw
The acute oral toxicity of the test item was evaluated in rats according to OECD guideline 401. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations.
The test item was prepared in Carboxymethyl cellulose at 05% and was administered by oral route (gavage), under a volume of 5 mL/kg bw, to groups of five fasted male and female Sprague-Dawley rats. The dose-levels of 500 and 2000 mg/kg bw were selected on the basis of the results obtained in a preliminary sighting study.
In the main study, clinical signs, mortality and body weight gain were checked for a period of up to 14 days following the single administration of the test item. All animals were subjected to necropsy.
At the 500 mg/kg bw dose-level, no mortality occured. A slight piloerection that appeared 30 minutes after the treatment and disappeared in less than 24 hours was the only clinical sign. The body weight gain of the animals was not affected by treatment with the test item and no apparent abnormalities were observed in any animal at necropsy.
At the 2000 mg/kg bwdose-level, 70% (4/5 males and 3/5 females) of the animals died within the study period. Most of the deaths occured 24 to 72 hours after treatment . An important piloerection, a slight abdominal meteorism and a dirty urogenital area were noted in the surviving animals from day 2 to day 8. All animals lost weight at 72 hours but females (not males) recovered at day 8. Necropsy of animals found dead revealed changes in liver, spleen, kidney, lung, intestine and abdominal wall. Necropsies of animals surviving until end of study did not reveal any changes.
Under these experimental conditions, the oral LD50of the test item was comprised between 500 and 2000 mg/kg in rats.
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