Registration Dossier
Registration Dossier
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EC number: 932-286-6 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1959
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited number of endpoints investigated (only clinical signs and hematogogy)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 10 rats were orally exposed to 0.25 mL/kg bw/day (201.5 mg/kg bw/day, being the density = 0.806 g/m³) of TDM for a period of 21 days
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- EC Number:
- 296-714-7
- EC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Cas Number:
- 93002-38-1
- Molecular formula:
- C12H26S
- IUPAC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Details on test material:
- - Name of test material (as cited in study report): TDM (tertiar dodecylmercaptan)
- Analytical purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2.5% - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 21 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.25 mL/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 10 (sex not reported)
- Control animals:
- not specified
- Details on study design:
- no further data reported
- Positive control:
- No
Examinations
- Observations and examinations performed and frequency:
- HAEMATOLOGY: Yes
- Sacrifice and pathology:
- Not reported
- Other examinations:
- No further data
- Statistics:
- Not reported
Results and discussion
Results of examinations
- Details on results:
- Animals´ blood count was normal.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
