Registration Dossier
Registration Dossier
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EC number: 932-286-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
TDM has low acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Additional information
In acute oral toxicity studies no mortality or clinical signs were observed at doses up to 5000 mg/kg-bw. At higher doses (10000 mg/kg-bw) clinical signs as reduced general condition and sedation were reported; mortality was seen only at the highest dose tested (15000 mg/kg-bw).
In an acute inhalation study no mortality or clinical signs were observed in rats exposed to 487 mg/m3 for 6 hours or rats and mice exposed to 202 mg/m3 for 4 hours. The reliability of this study is not assignable because of the limited documentation, the experimental conditions (not performed according to actual guidelines), the analytical determination of test atmosphere (not performed according to actual guidelines) and the low TDM concentration in the test atmosphere compared to actual guideline requirements.
The intraperitoneal injection of 1.0 or 2.5 mL TDM / kg-bw (861 mg/ kg bw and 2152 mg/kg bw respectively) to 3 rats caused no apparent signs of toxicity.
Justification for classification or non-classification
LD50 ca. 15000 mg/kg-bw after acute oral dosing; no reliable acute data are available after dermal or inhalation exposure.
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