Registration Dossier
Registration Dossier
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EC number: 932-286-6 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1959
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A cotton swab impregnated with the test substance was applied into the interior of a rabbit ear by means of adhesive bandage for a period of 4 and 8 hours
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- EC Number:
- 296-714-7
- EC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Cas Number:
- 93002-38-1
- Molecular formula:
- C12H26S
- IUPAC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Details on test material:
- - Name of test material (as cited in study report): TDM (tertiar dodecylmercaptan)
- Analytical purity: not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Not reported
- Duration of treatment / exposure:
- 4 and 8 hours
- Observation period:
- not reported
- Number of animals:
- not reported
Results and discussion
In vivo
- Irritant / corrosive response data:
- At the end of the 4-hour exposure a temporary slight reddening of the skin was observed at the exposure site. Later, a slight scabbing was noted at the same site. After 8-hour exposure a strong reddening and swelling of the skin was observed.
Any other information on results incl. tables
At the end of the 4-hour exposure a temporary slight reddening of the skin was observed at the exposure site. Later, a slight scabbing was noted at the same site. After 8-hour exposure a strong reddening and swelling of the skin was observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
