Registration Dossier
Registration Dossier
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EC number: 932-286-6 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not conducted according to actual guidelines; limited documentation; analytical determination of test atmosphere not performed according to actual guidelines.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dynamic acute inhalation study (vapour)
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- EC Number:
- 296-714-7
- EC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Cas Number:
- 93002-38-1
- Molecular formula:
- C12H26S
- IUPAC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Details on test material:
- - Name of test material (as cited in study report): TDM (tertiar dodecylmercaptan)
- Analytical purity: not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Kirchborchen, Germany
- Weight at study initiation: 160-180 g
- Housing: Makrolon cages type III
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic inhalation apparatus
- Exposure chamber volume: 20 L
TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography with help of flame ionization detector - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 6 h
- Concentrations:
- 487 mg/m³
- No. of animals per sex per dose:
- 10
- Control animals:
- other: not necessary
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 487 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- No mortality occurred
- Clinical signs:
- other: No symptom was detected after the exposure during the 14-day exposure period
- Body weight:
- Not reported
- Gross pathology:
- Not reported
Applicant's summary and conclusion
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