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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions (analytical purity not reported; method shortly described; 95% CL not reported)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
analytical purity not reported; method shortly described; 95% CL not reported
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2,4,6,6-pentamethylheptane-4-thiol
EC Number:
296-714-7
EC Name:
2,2,4,6,6-pentamethylheptane-4-thiol
Cas Number:
93002-38-1
Molecular formula:
C12H26S
IUPAC Name:
2,2,4,6,6-pentamethylheptane-4-thiol
Details on test material:
- Name of test material (as cited in study report): TDM (tertiar dodecylmercaptan)
- Analytical purity: not reported

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Winkelmann, Kirchborchen, Germany
- Weight at study initiation: 160-180 g
- Housing: Makrolon cages type III
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
no further data
Doses:
5000, 10000, 15000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
other: not necessary
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Statistics:
The calculation of the median lethal dose (LD50) was performed by Probit-analysis (Fink, H. et al., 1966. Methods of information in medicin 5, 19, 1966)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
15 000 mg/kg bw
Based on:
test mat.
Mortality:
4/10 animals belonging to the highest exposure group died between the second and the fifth day after exposure.
Clinical signs:
other: The animals belonging to the mid and high dose exposure groups showed a reduction of their general condition and sedation.
Gross pathology:
Not examinated
Other findings:
No further data

Any other information on results incl. tables

Doses mg/kg

Toxicological Findings

Occurrence of death

LD50(14 days) mg/kg

5000

0/0/10

-

Approximately 15000

10000

0/10/10

-

15000

4/10/10

2-5d

1st digit: Number of death animals

2nd digit: Number of animals with symptoms

3rd digit: Number of animals used

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: DSD and CLP